The Value of Combining Serum Alanine Aminotransferase Levels and Body Mass Index to Predict Mortality and Medical Costs : a 10-year Follow-up Study of National Health Insurance in Shiga, Japan
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概要
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BACKGROUND: Evidence suggests that the predictive value of serum alanine aminotransferase (ALT) levels for prognosis, measured by indices such as all-cause mortality and medical costs, may be modified by body mass index (BMI). However, the relationship between serum ALT and BMI has not been satisfactorily elucidated.METHODS: Four thousand, five hundred and twenty-four community dwelling Japanese National Health Insurance beneficiaries, 40-69 years old, were classified into five categories according to their serum ALT levels (IU/L) (ALT<20, 20≤ALT<30, 30≤ALT<40, 40≤ALT<50 and 50≤ALT) and followed for 10 years. Hazard ratios for all-cause mortality, with reference to the lowest serum ALT category, and medical costs per person were evaluated for each serum ALT category after analyzing interactions between serum ALT levels and BMI for all-cause mortality and for medical costs.RESULTS: A significant interaction between serum ALT levels and BMI was observed. In participants below the median BMI, positive, graded relationships were identified between serum ALT levels and allcause mortality as well as between serum ALT levels and personal medical costs. The multivariateadjusted hazard ratio in the "50≤ALT" category showed an approximately 8-fold increase. However, in the participants at or above the median BMI, no significant relationships between serum ALT levels and all-cause mortality or personal medical costs were identified.CONCLUSIONS: In these Japanese participants, the predictive value of serum ALT levels for prognosis was more evident if BMI was taken into account. A combination of high serum ALT levels and below median BMI was associated with excess mortality and medical costs.J Epidemiol 2006; 16: 15-20.
- 日本疫学会の論文
- 2006-01-01
著者
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Ueshima Hirotsugu
Department of Health Science, Shiga University of Medical Science
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Okamura Tomonori
Department of Preventive Cardiology, National Cardiovascular center
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Hayakawa Takehito
Department of Hygiene and Preventive Medicine, Fukushima Medical University
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OKAYAMA Akira
Department of Preventive Cardiology, National Cardiovascular Center
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Nakamura Koshi
Department of Epidemiology and Public Health, Kanazawa Medical University
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KANDA Hideyuki
Department of Hygiene and Preventive Medicine, Fukushima Medical University
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Okayama Akira
Department Of Orthopedic Surgery Hyogo College Of Medicine
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Nakamura Koshi
Department Of Epidemiology And Public Health Kanazawa Medical University
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Kanda Hideyuki
Department Of Hygiene And Preventive Medicine Fukushima Medical University
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Kanda Hideyuki
Department Of Hygiene & Preventive Medicine Fukushima Medical University
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Ueshima Hirotsugu
Department Of Health Sceicne Shiga University Of Medical Science
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Hayakawa Takehito
Department Of Hygiene And Preventive Medicine Fukushima Medical University
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Okayama Akira
Department Of Hygiene And Preventive Medicine Osaka University School Of Medicine Nakanoshima
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Okamura Tomonori
Department Of Cardiology National Cardiovascular Center
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Hayakawa Takehito
Division Of Epidemiology And Prevention Aichi Cancer Center Research Institute
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Hayakawa Takehito
Department Of Cancer Control And Statistics Osaka Medical Center For Cancer And Cardiovascular Diseases:for The Hipop-ohp Research Group
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- Preface
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