Effect of Anti-CD14 Antibody on Experimental Periodontitis Induced by Porphyromonas gingivalis Lipopolysaccharide
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概要
- 論文の詳細を見る
The lipopolysaccharide (LPS) released by Porphyromonas gingivalis, a Gram-negative bacterium found in the periodontal pockets of patients with periodontitis, induces bone resorbing activity in vivo. We previously showed that a receptor for LPS on human gingival fibroblasts and gingival epithelial cells is CD14. In this study, we established a mouse model of experimental periodontitis by applying a P. gingivalis LPS solution to the buccal region of mice. P. gingivalis LPS-induced bone resorption and interleukin-6 production in the gingival tissues were significantly inhibited by pretreatment with anti-CD14 antibody for 5 weeks prior to LPS treatment. This result suggests that anti-CD14 antibody may be usable as a prototype for the development of drugs for the treatment of periodontal disease.
- 社団法人 日本薬理学会の論文
- 2002-06-01
著者
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Wang Pao-Li
Department of Pharmacology, Matsumoto Dental University
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Wang Pao-li
大阪歯科大学 薬理
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Fujii Takeo
Department Of Periodontology And Endodontology School Of Dentistry Health Sciences University Of Hok
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Fujii Takeo
Department Of Electrical And Electronic Engineering Shizuoka University
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Wang P‐l
Osaka Dental Univ. Hirakata Jpn
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Wang Pao-li
Department Of Dental Pharmacology Matsumoto Dental University
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SHINOHARA Mitsuko
Department of Pharmacology, Osaka Dental University
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OHURA Kiyoshi
Department of Pharmacology, Osaka Dental University
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KOWASHI Yusuke
Department of Periodontology, Health Sciences University of Hokkaido
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Kikuchi Masanori
Biomaterial Center, National Institute for Materials Science
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TANAKA Junzo
National Institute for Research in Inorganic Materials
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AZUMA Yasutaka
Department of Pharmacology, Osaka Dental University
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TANAKA Junzo
Biomaterials Center, National Institute for Materials Science
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Oido Mari
Department Of Periodontology And Endodontology School Of Dentistry Health Sciences University Of Hok
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Tanaka Junzo
Biomaterials Center National Institute For Materials Science
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Ohura Kiyoshi
Department Of Pharmacology Osaka Dental University
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Kowashi Yuske
Department Of Periodontology And Endodontology School Of Dentistry Health Sciences University Of Hok
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Azuma Yasutaka
Department Of Pharmacology Osaka Dental University
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Kikuchi Masanori
Biomaterials Center National Institute For Materials Science
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OIDO-MORI Mari
Department of Periodontology and Endodontology, School of Dentistry, Health Sciences University of H
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KIKUCHI Masanori
National Institute for Materials Science, Advanced Materials Laboratory, Bioceramics Research Group
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SUETSUGU Yasushi
National Institute for Materials Science, Advanced Materials Laboratory, Bioceramics Research Group
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Tanaka Junzo
National Institute For Materials Science
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Kikuchi M
Biomaterials Center National Institute For Materials Science
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Shinohara Mitsuko
Department Of Pharmacology Osaka Dental University
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Wang Pao-li
Department Of Dental Education And Development Osaka Dental University
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Kikuchi M
Biomaterial Center National Institute For Materials Science
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Suetsugu Yasushi
Biomaterials Center National Institute For Materials Science
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Kikuchi Masanori
Crest Jst:biomaterial Center Nims
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Kowashi Yusuke
Department Of Periodontology And Endodontology School Of Dentistry Health Sciences University Of Hok
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Oido Mari
Department Of Periodontology And Endodontology School Of Dentistry Health Sciences University Of Hok
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Ohura K
Department Of Pharmacology Osaka Dental University
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Kikuchi Masanori
Department Of Mineral Resources Engineering School Of Science And Engineering Waseda University
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Shinohara M
Osaka Dental Univ. Osaka Jpn
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Fujii Takeo
Department Of Dental Radiology School Of Dentistry Institute Of Health Sciences University Of Hokkai
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