The Sonochemical and Biological Effects of Three Clinically-Used Contrast Agents
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概要
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The encapsulation of gas bubbles has resulted in improved stability and added a binding capacity to shells for ultrasound-guided targeted delivery. However, this has also changed the physical and acoustical properties of the final formulation. In this study, we have evaluated three clinically-used contrast agents of different compositions, namely, Levovist, Sonazoid, and SonoVue, with respect to their sonochemical and biological effects at different concentrations. The results showed that both shell elasticity and reactivity played a role in modulating both effects influencing the extent of ultrasound-induced free-radical formation. Microbubbles with elastic shells were found to be more capable of inducing delayed symptoms of cell killing, whereas the combined use of chemically reactive robust shells and high-density gases, such as perfluorocarbons, could exert a protective effect on cells. These conclusions offer new perspectives on how microbubbles interact with biological systems and might be useful in tailoring novel microbubbles in the future.
- 2010-07-25
著者
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Feril Jr.
Department Of Radiological Sciences Faculty Of Medicine Toyama Medical And Pharmaceutical University
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Hassan Mariame
Department Of Radiological Sciences Graduate School Of Medicine And Pharmaceutical Sciences Universi
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Tachibana Katsuro
Department Of Anatomy Fukuoka University School Of Medicine
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Riesz Peter
Radiation Biology Branch National Cancer Institute
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Kudo Nobuki
Laboratory Of Biochemical Instrumentation & Measurements Research Associate Graduate School Of E
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Kondo Takashi
Department Of Agricultural Chemistry The University Of Tokyo
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Hassan Mariame
Department of Radiological Sciences, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan
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Tachibana Katsuro
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt
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Riesz Peter
Radiation Biology Branch, National Cancer Institute, NIH, Bethesda, MD 20892-1002, U.S.A.
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Riesz Peter
Radiat. Biol. Branch, NCI, NIH
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