DNA Microarray Analysis of Differentially Expressed Genes Responsive to Bisphenol A, an Alkylphenol Derivative, in an In Vitro Mouse Sertoli Cell Model
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概要
- 論文の詳細を見る
To identify genes elicited by bisphenol A (BPA) in Sertoli cells, we carried out a microarray analysis of TTE3 cells (a mouse Sertoli cell line) treated with BPA. BPA (100, 200 and 400 μM) induced cell death concentration-dependently, with levels being 25%, 33% and 96%, respectively. Of the 1,081 genes analyzed, 3 genes showed decreased levels of expression while the remaining 10 genes showed increased levels in the cells treated with a subtoxic dose of BPA (200 μM). The expressions of six genes were confirmed by the TaqMan assay. These findings suggest that DNA microarray analysis is a useful tool for investigating the molecular mechanisms of the toxic effects of BPA in testicular cells.
- 社団法人 日本薬理学会の論文
- 2002-08-01
著者
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KONDO Takashi
Department of Thoracic Surgery, Tohoku University Graduate School of Medicine
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Kondo Takashi
Department Of Radiological Sciences Graduate School Of Medicine And Pharmaceutical Sciences Universi
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TABUCHI Yoshiaki
Molecular Genetics Research Center
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ZHAO Qing-Li
Department of Radiological Sciences, Faculty of Medicine, Toyama Medical and Pharmaceutical Universi
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Zhao Qing-li
Department Of Radiological Sciences Graduate School Of Medicine And Pharmaceutical Sciences Universi
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Kondo T
Osaka Univ. Osaka Jpn
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Zhao Q‐l
Department Of Radiological Sciences Faculty Of Medicine Toyama Medical And Pharmaceutical University
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Tabuchi Yoshiaki
Second Department Of Surgery Graduate School Of Medicine And Pharmaceutical Sciences University Of T
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Zhao Qing
Dept. Of Radiation Biophysics And Genetics Kobe Univ. School Of Medicine.
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Kondo Takashi
Department Of Diagnostic Radiology Tohoku University School Of Medicine
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Kusaka Takashi
Department Of Pediatrics Faculty Of Medicine Kagawa University
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Tabuchi Y
Second Department Of Surgery Graduate School Of Medicine And Pharmaceutical Sciences University Of T
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Zhao Qing
Dept. Radiol. Sci. Toyama Medical And Pharmacutical Univ
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Zhao Qing-li
Department Of Radiological Sciences Faculty Of Medicine Toyama Medical And Pharmaceutical University
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Zhao Qing-li
Department Of Radiological Sciences Graduate School Of Medicine And Pharmaceutical Sciences Universi
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Zhao Qing-li
Department Of Radiological Sciences Graduate School Of Medicine And Pharmaceutical Sciences Universi
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Kondo Takashi
Department Of Chemical Engineering Waseda University
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Kondo Takashi
Department Of Applied Physics Faculty Of Engineering The University Of Tokyo
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Kondo Takashi
Department Of Agricultural Chemistry The University Of Tokyo
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