S25. Gene regulation and sonotransfection by low-intensity ultrasound resulting in malignant melanoma inhibition(Oral Presentation)
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概要
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To investigate the effects of low-intensity ultrasound on human malignant melanoma (C-32), cells in vitro and C-32 tumor in mice were exposed to 0.1-0.5 W/cm^2 (1.011-MHz) ultrasound. In another experiments, cells in vitro and in vivo were sonotransfected with the following genes: GFP, IFN-beta, and GFP tagged IFN-beta gene, after micro-bubbles were added. Two minutes daily sonication resulted in growth inhibition. Neither significant cell killing nor change in cell migration activity was observed, but several genes were either up- or down-regulated. Sonotransfection with IFN-beta resulted in cell killing, apoptosis induction and overall growth inhibition of melanoma. While GFP sonotransfection did not significantly affect cell growth, it was shown that cells transfected with GFP-tagged IFN-beta genes were more likely to undergo apoptosis. In addition, growth of cells sub-cultured with sonotransfected cells was also inhibited. These findings suggest the potential use of low-intensity ultrasound against malignant melanoma.
- 日本ソノケミストリー学会の論文
- 2011-10-15
著者
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TABUCHI Yoshiaki
Division of Molecular Genetics Research, Life Science Research Center, University of Toyama
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Feril Loreto
Department Of Anatomy Fukuoka University School Of Medicine
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Furusawa Yukihiro
Department Of Radiological Sciences Graduate School Of Medicine And Pharmaceutical Sciences Universi
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Tachibana Katsuro
Department Of Anatomy Fukuoka University School Of Medicine
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Ikeda-dantsuji Yurika
Department Of Microbiology And Immunology Faculty Of Medicine Fukuoka University
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Yamaguchi Kazuki
Department Of Anatomy Fukuoka University School Of Medicine
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Takasaki Ichiro
Division Of Molecular Genetic Research Life Science Research Center University Of Toyama
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Kondo Takashi
Department Of Agricultural Chemistry The University Of Tokyo
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Tabuchi Yoshiaki
Division Of Molecular Genetics Research Life Science Research Center University Of Toyama
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Ikeda-Dantsuji Yurika
Department of Microbiology and Immunology, Fukuoka University School of Medicine
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