S10. Studies on the Biological and Chemical Effects of Ultrasound : Implications in Drug Delivery and Cancer Therapy(Oral Presentation)

概要

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The versatility of biological effects induced by low-intensity ultrasound across a wide range of applications paint ultrasound a positive light as a tool in cancer therapy and drug delivery. However, further understanding of how changing ultrasound parameters can alter the acoustic environment and hence, the cellular responses, is required to help promote the translational research of therapeutic ultrasound. In this respect, we will summarize here our studies on the biological and sonochemical effects at different acoustic conditions and their implications in ultrasound-aided macromolecular delivery, drug sonosensitization and reversal of multidrug resistance. From the results shown here we will present a discussion on how ultrasound can be a "two-edged sword" which necessitates treading new roads in understanding the interaction between US and biological systems, especially when it approaches a genetic level.
日本ソノケミストリー学会の論文
2011-10-15