Biomolecular Effects of Low-Intensity Ultrasound: Apoptosis, Sonotransfection, and Gene Expression

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概要

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• Biological effects of low-intensity ultrasound (US) focusing on US-induced programmed cell death (apoptosis), regulation of gene expression, and US-mediated gene transfection (sonotransfection) are reviewed. Studies have shown that US can induce apoptosis and that certain conditions can provide an optimal apoptosis induction. Sonotransfection of different cell lines in vitro and target tissues in vivo have been reported. Several genes can also be up-regulated or down-regulated by sonication. As to the potential therapeutic applications, apoptosis induction by US may induce direct and fast ways of treating tumor or cancer tissues. Systemic or local sonotransfection might also be a safe and effective gene therapy method in effecting the cure of local and systemic disorders. Gene regulation of target cells may be utilized in modifying cellular response to a treatment, such as increasing the sensitivity of diseased cells while making normal cells resistant to the side effects of the treatment. In addition, gene regulation by US may also play an important part in the enhanced healing of damaged tissues.

• Published by the Japan Society of Applied Physics through the Institute of Pure and Applied Physicsの論文
• 2007-07-30

著者

• Feril Jr.

  Department Of Radiological Sciences Faculty Of Medicine Toyama Medical And Pharmaceutical University

• Ogawa Ryohei

  Department Of Applied Chemistry School Of Science And Engineering Waseda University

• Nozaki Tetsuo

  Department Of Urology Faculty Of Medicine Toyama Medical And Pharmaceutical University

• Tachibana Katsuro

  Department Of Anatomy Fukuoka University School Of Medicine

• Kudo Nobuki

  Laboratory Of Biochemical Instrumentation & Measurements Research Associate Graduate School Of E

• Zhao Qing-li

  Department Of Radiological Sciences Faculty Of Medicine Toyama Medical And Pharmaceutical University

• Yoshida Toru

  Department Of Emergency And Critical Care Medicine St. Marianna University School Of Medicine

• Kondo Takashi

  Department Of Agricultural Chemistry The University Of Tokyo

• Tabuchi Yoshiaki

  Division Of Molecular Genetics Research Life Science Research Center University Of Toyama

• Feril Loreto

  Department of Anatomy, Fukuoka University School of Medicine, Fukuoka 814-0180, Japan

• Tabuchi Yoshiaki

  Division of Molecular Genetics Research, Life Sciences Research Center, University of Toyama, Toyama 930-0194, Japan

• Zhao Qing-Li

  Department of Radiological Sciences, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan

• Tachibana Katsuro

  Department of Anatomy, Fukuoka University School of Medicine, Fukuoka 814-0180, Japan

• Ogawa Ryohei

  Department of Radiological Sciences, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan

• Nozaki Tetsuo

  Department of Urology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan

• Kondo Takashi

  Department of Radiological Sciences, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan

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