Study of CH50 and Proteins in the Blood in Hyperuricemia

概要

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In 22 patients with hyperuricemia, measurements of the CH50, the proteins of complement-system, proteinase inhibitors, plasminogen and fibrinogen in the blood were carried out, in order to find out pathophysiological response into sodium urate deposition. Significant increase of C4, C3, C3-Activator and fibrinogen was generally present in patients with hyperuricemia as compared to normal control. In patients with previous history of gouty attack, these changes became more prominent and CH50 and C1q also showed significant increase. The documentation of these finding which were obtained in non-acute phase, suggests us the presence of more or less pathophysiological changes in the background of hyperuricemic patients. And study of these complement activity and proteins in the blood might be significant procedures to support diagnosis ot so-called asymptomatic nyperuricemia.
Japanese Society of Gout and Nucleic Acid Metabolismの論文