泌尿器系悪性腫瘍患者における血清蛋白異常 : 第3報補体系及びProteinase Inhibitorの変動について

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In 34 cases of cancers of the urogenital tract such as the bladder, the prostate, and the kidneys, the total hemolytic complement (CH_<50>), the proteins of the complement-system (C_<1q>, C_<1s>, C_4, C_3, C_5, C_9, C_<3a> and C_3-A) and the proteinase inhibitors (C_<1s>,-INH, AT-III, α_1-AT and α_2-M) in the serum were measured. Our results are summarized in the following. 1) Among the proteins of the complement-system, C_9 was found to be remarkably elevated in the cases of cancer in the urogenital tract, and its elevation became more predominant as the stage of the illness progressed. 2) C_<1s>,-INH showed a significant increase along with the progression of cancer. The presence of a close correlationship between C_<1s>,-INH and C4 was documented. 3) C_3-A also demonstrated a tendency to increase as the stage of cancer progressed. A close correlationship between C_3-A and C_<3a> was observed. 4) AT-III, which showed a generalized tendency to decrease in the cases of cancer, demonstrated a marked decrease in the cases of cancer of the prostate. 5) α_1-AT showed a tendency to increase in all cases and α_2-M showed the same tendency only in male cases of cancer. From these studies, it is concluded that the presence of a generalized increase of the complement-system in the serum of the cases of cancer in the urogenital tract is confirmed and these findings should be considered pathophysiologically in close association with previously well-documented findings of a decrease of fibrinolytic activity and an increased activation of coagulation system in the blood in the cases of cancer, and it is also speculated that these changes might possibly be supplying a favorable environment for the progression of cancer.
社団法人日本泌尿器科学会の論文

泌尿器系悪性腫瘍患者における血清蛋白異常 : 第3報補体系及びProteinase Inhibitorの変動について

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