Studies on Animal Model of Hereditary Gout:Studies on Animal Model of Hereditary Gout Effects of High Protein Diet on Purine Metabolism of hereditary Gouty Chickens

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The effects of a high protein diet on purine metabolism in gouty and non-gouty chickens were compared. The daily urinary urate excretion were compared in gouty and non-gouty chickens fed a high protein (40%) and a normo protein (17%) diets. The daily urinary urate excretion in gouty chicken on high protein diet was more than that in non-gouty ones. The activities of six enzymes involved in purine metabolism (G-PRPP-AT, PRPP synthetase, glutamine synthetase, HGPRT, APRT and xanthine dehydrogenase) in the livers of gouty and non-gouty chickens on high and normo protein diets were also compared. The activities of G-PRPP-AT and glutamine synthetase in gouty chicken were more highly induced by a high protein diet than in non-gouty ones. In contrast, HGPRT and APRT activities in gouty chicken were decreased by a high protein diet while those in non-gouty ones were increased. A high protein diet induced PRPP synthetase and xanthine dehydrogenase in similar extent in gouty and nongouty chickens. The hepatic contents of PRPP, glutamine, oxypurine and urate were estimated. A high protein diet increased the hepatic PRPP content both in gouty and non-gouty chickens. On the other hand, the hepatic glutainine content in gouty chicken was decreased by a high protein diet, but not in non-gouty ones. Increase of urate content in the liver was observed only in gouty chicken, and it was twice in nongouty ones. These results suggest that the excessive supply of glutamine is one of the important factors in the accelerated purine and urate biosynthesis in gouty chicken.
Japanese Society of Gout and Nucleic Acid Metabolismの論文

Studies on Animal Model of Hereditary Gout:Studies on Animal Model of Hereditary Gout Effects of High Protein Diet on Purine Metabolism of hereditary Gouty Chickens

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