カドミウム投与ラットにおけるアルカリホスファターゼ活性の変動

概要

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When cadmium (CdCl_2) was administered subcutaneously in a high single dose of 5.0 mg/kg to rats, their liver and testis tissues showed a statistically significant increase in alkaline phosphatase (Al-P) activity at 24 h or more after the administration while the reverse was the case in the serum of the rats. Lactate dehydrogenase (LDH) activity in the serum showed a statistically significant decrease at 15 to 24 h after the administration of CdCl_2. An increase in LDH activity for the serum coincided with that for the testis. During the study period there was no change in the calcium level in the serum, but the level of zinc in the serum decreased in a similar fashion to serum Al-P activity. As for the level of cadmium in the serum, it showed a very high value (ca. 0.03 mM) at 15 and 24 h after CdCl_2 administration. When this concentration of cadmium was added in the form of CdCl_2 to rat serum in vitro, it produced an inhibitory effect on serum Al-P activity. These facts suggest that the decrease in serum Al-P activity is not due to a change in tissue levels of Al-P, but reflects a direct inhibition of Al-P activity in the serum by cadmium.
公益社団法人日本薬学会の論文
1984-10-31