Studies on Animal Model of hereditary Gout.:Uric Acid Contents and Xanthine Dehydrogenase (XDH) Activities in Viscera of Hereditary Gouty Chickens

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Uric acid contents and xanthine dehydrogenase (XDH) activities in viscera of Fayoumi chickens which had been selected for animal model of hereditary gout were assayed to observe the distribution of the uric acid in viscera, when normal or high protein diets were fed for 2 weeks in the adult stage. Uric acid contents in viscera were increased by feeding a high protein diet. The interaction of genotype (gouty or non-gouty) and protein (a normal protein diet composed of 17% crude protein and a high protein diet composed of 40% crude protein) were observed. The interaction of genotype and protein level were different among organs. Especially, in the liver and the aorta, the multiplicative interactions were observed. The increase of the uric acid in the aorta of the gouty chicken fed on a high protein diet may suggest some relationship to the atherosclerosis. XDH activity levels in viscera of adult chickens were as follows: liver> kidney> spleen, irrespective to the diets. That in the heart was not able to be detected by the present method. XDH activities in the liver and the kidney were increased when fed on a high protein diet.
Japanese Society of Gout and Nucleic Acid Metabolismの論文