カドミウムによる精巣障害の発症過程における脂質過酸化の関与について
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To investigate when the changes of lipoperoxide contents in early stage of the inflammation are induced in the testis of rats after CdCl_2 injection, we measured the lipoperoxide contents in plasma and tissues (liver, kidney and testis) at 1,3,5,10,15,24 and 48 h after CdCl_2 (5.0 mg/kg) injection. Lipoperoxide value in the testis increased significantly from 15 h after CdCl_2 injection. Although no change of lipoperoxide value was observed in the liver through the experimental period, the value in the kidney increased significantly at 10 and 48 h after CdCl_2 treatment. Heme protein value which represents the degree of hemorrhage in the testis also increased from 15 h after CdCl_2 injection. This suggests that hemorrhage in the testis has a good correlation with an increase in lipid peroxidation in situ. The fact that significant increases in lipoperoxide values and in the degree of hemorrhage were observed from 15 h after CdCl_2 injection, reveals the possibility that oxidative reactions occur in the testis of rats nearly 15 h after the treatment. Assay of enzyme activities in serum was performed simultaneously. The activity of β-glucuronidase which is considered to be one of parameters showing the occurrence of an inflammation, increased significantly at an early time (from 1 to 5 h) after CdCl_2 treatment. This implies that some biochemical reactions occur in the testis before the time when the increase of lipoperoxide formation occurs. In the liver where no fluctuation of lipoperoxide concentration was observed during the experimental period, the Zn contents increased as the time elapsed after CdCl_2 administration. On the contrary, a significant reduction of the Zn content was observed in the testis in which a considerable increase in lipoperoxide concentration was noticed, at 3-5 h after CdCl_2 administration. The inflammation of testis by Cd is supposed to be initiated at this time stage. The difference of the Zn contents in these tissues may be considered to be one of factors which induce the difference among tissues in lipoperoxide concentration.
- 公益社団法人日本薬学会の論文
- 1983-12-31
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