カドミウムによる精巣障害関連因子の経時的変化について

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Long-term experiments were carried out, for up to 300 d after CdCl_2 injection, to investigate the mechanism of the testis injury induced by CdCl_2. The results are summarized as follows ; 1) Testis weight and lipoperoxide concentration were increased significantly at 3 d after CdCl_2 injection, and thereafter decreased steadily. The values at 300 d were very much lower than those of control group. 2) Although hemoglobin content in the testes treated with CdCl_2 was significantly higher at 3 d, presumably because of the intensive hemorrhage in situ, it decreased gradually and the value at 300 d after injection had returned almost to the control level. 3) In the testis at 3 d after CdCl_2 injection, edematous was found in the interstitial tissue numerous neutrophils had migrated into the seminiferous tubules and the tubules were contracted. These changes, however, disappeared as time elapsed after CdCl_2 injection. By 300 d, the seminiferous tubules were filled with materials which had a high concentration of Ca and P. The concentration of Ca in the interstitial tissues was also high. The enhancement of Ca deposition was observed in the testes of rats 3 d after CdCl_2 injection. 4) Although the activities of serum GOT and GPT were significantly higher at 3 d after CdCl_2 administration, they returned to the control level by 15 d after the injection and thereafter they showed normal values throughout the remainder of the observation periods. On the contrary, Al-P activity decreased significantly at 3 d after the injection. However, the enzyme activity returned to the control level at 90 d.
社団法人日本薬学会の論文
1984-08-31

カドミウムによる精巣障害関連因子の経時的変化について

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