The Clinical Significance of Hyper-and Hypo-uricemia

概要

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Hyperuricemia was noted in 22.4% of 20,723 consecutive serum urate measurements at our hospital and hypouricemia was noted in 1.8%. The purpose of the present study was to determine the clinical significance of these abnormal serum urate values. The results are as follows: 1. In hyperuricemia, the frequency of the cardio-vascular diseases was 55.6%. The frequency of malignant tumor, urolithiasis, renal failure, liver dysfunction and hypercholesteremia was higher than that of normal controls significantly. In addition, it was found in hyperuricemia to correlate between the degree of serum urate concentration and the frequency of gouty arthritis, ishemic heart disease, cerebral vascular disturbance and renal failure. 2. In hypouricemia, malignant tumor, low proteinemia, liver dysfunction and diabetes mellitus were commonly complicated. The pathogenesis of liver dysfunction and diabetes showing hypouricemia is an attractive study in comparison to that with hyperuricemia 3. Hypouricemia is significant in so-called idiopathic hypouricemia but less in clinical occurrence.
Japanese Society of Gout and Nucleic Acid Metabolismの論文