High performance liquid chromatography of formaldehyde in indoor air using miniature diffusion scrubber and 2,4-pentanedione

概要

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Stimulatibility, mutagenicity and carcinogenicity have been indicated the formaldehyde which exist for the indoor environment. Therefore, the guideline has been instituted on the formaldehyde in the indoor air in WHO and Japan. HPLC and GC method using the DNPH cartridge are widely used for the measuring method of the formaldehyde in indoor air. However, mutagenicity and carcinogenicity have been indicated the DNPH method in reagent itself, and they grope for the new method for replacing it. In this study, the 2,4-pentanedione solution (ammonium acetate, acetic acid, 2,4-pentanedione) without the harmfulness was made to be the collecting solution, and it examined the method for using Miniature Diffusion Scrubber (MDS) for the sampling. The form formaldehyde reacts under the existence of ammonium acetate with 2,4-pentanedione, and the measurement principle of this method forms derivative (3,5-diacetyl-1, 4-dihydrolutidine). The derivative is measured by the HPLC with ultraviolet detector (413 nm). The determination limit of this method is 0.012 ppm in the case of 1 L sampling. In this method, the effect of SO2, NO2 and O3 of indoor level is not received. Significant correlation was observed between this method and JIS method (active sampling method). From the above mention result, the practicability of this method was confirmed.