Central Nervous System Relapse of Whipple's Disease
スポンサーリンク
概要
- 論文の詳細を見る
A 50-year-old man presented with a 12 kg weight loss in 8 months. Upper gastrointestinal endoscopy findings showed strong erosion and diffuse bleeding in the duodenum. Histopathological findings showed PAS staining-positive macrophages consistent with Whipple's disease. He was treated with trimethoprim-sulfamethoxazole. His condition initially improved. However, during his 6-year course of treatment he developed a central nervous system relapse. Tropheryma whipplei DNA was detected by a polymerase chain reaction in his cerebrospinal fluid. This relapse was successfully treated with ceftriaxone sodium (CTRX). We considered that as initial therapy for Whipple's disease, it would be important to administer CTRX for at least a few months, due to its high translatability to CSF.
著者
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Yamashita Kenichi
Department Of Applied Chemistry School Of Engineering Kyushu University
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Sakai Takashi
Department Of Applied Chemistry Faculty Of Engineering Okayama University
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Yamamoto Tomonori
Department Of Biological Science And Technology Science University Of Tokyo
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Yamamoto Tomonori
Department of Gastroenterology, Yao Tokushukai General Hospital, Japan
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Willard Yoshie
Department of Cytology, Yao Tokushukai General Hospital, Japan
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Harada Hiromasa
Department of Respiratory Medicine, Yao Tokushukai General Hospital, Japan
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Mae Takahito
Department of Respiratory Medicine, Yao Tokushukai General Hospital, Japan
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Uryu Kiyoaki
Department of Respiratory Medicine, Yao Tokushukai General Hospital, Japan
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Sugita Hiroji
Department of Gastroenterology, Yao Tokushukai General Hospital, Japan
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Asano Koukichi
Department of Gastroenterology, Yao Tokushukai General Hospital, Japan
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Fukuda Kou
Department of Cardiovascular Medicine, Yao Tokushukai General Hospital, Japan
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