Asymmetric reduction of .ALPHA.-(dimethylthiocarbamoylthio) carbonyl compounds with bakers' yeast.

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概要

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• Treatment of α-(dimethylthiocarbamoylthio) ketones with bakers' yeast afforded the corresponding chiral alcohols in high yields with high enantiomeric excess (in most cases, more than 96% ee). α-(Dimethylthiocarbamoylthio) aldehydes were reduced to give chiral α-(dimethylthiocarbamoylthio) alcohols in 69–92% yields with 32–63% ee, which were converted to chiral 1,2-epithio derivatives.

• 公益社団法人 日本化学会の論文

著者

• Tsuboi Sadao

  Department Of Applied Chemistry Faculty Of Engineering Okayama University

• Utaka Masanori

  Department Of Applied Chemistry Faculty Of Engineering Okayama University

• Doi Katsumi

  Department of Synthetic Chemistry, School of Engineering, Okayama University

• DOI KATSUMI

  Department of Internal Medicine, School of Medicine, Keio University

• Takeda Akira

  Department of Applied Chemistry, Faculty of Engineering, Okayama University

• Kohara Noriyuki

  Department of Synthetic Chemistry, School of Engineering, Okayama University

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