The Reaction of Ethyl Alkylchloropyruvate with Sodiomalonate and Sodioacetoacetate
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概要
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The reaction of alkylchloropyruvate (<B>1</B>) with sodiomalonate gave γ-alkyl-α,β-dialkoxycarbonyl-<I>Δ</I><SUP>β,γ</SUP>-butenolide (<B>2</B>), which led to γ-ketocarboxylic acid (<B>3</B>). The reaction of <B>1</B> with sodioacetoacetate gave 2-alkyl-5-methylfuran-3,4-dicarboxylate (<B>6</B>) <I>via</I> the intermediate 2-alkyl-3-hydroxy-5-methyl-2,3-dihydrofuran-3,4-dicarboxylate (<B>5</B>). It has been shown unambiguously that the carbanions of both sodiomalonate and sodioacetoacetate attack the carbonyl carbon of <B>1</B> predominantly.
- 公益社団法人 日本化学会の論文
著者
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Takeda Akira
Department Of Gastroenterology Osaka General Medical Center
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Nakasima Isao
Department of Synthetics Chemistry, School of Engineering, Okayama University
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Wada Satosi
Department of Synthetics Chemistry, School of Engineering, Okayama University
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Fujii Masatosi
Department of Synthetics Chemistry, School of Engineering, Okayama University
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Hirata Shoiti
Department of Synthetics Chemistry, School of Engineering, Okayama University
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Takeda Akira
Department of Applied Chemistry, Faculty of Engineering, Okayama University
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