A new synthesis of 4-methoxy-6-valeryl-5,6-dihydro-2-pyrone.
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概要
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The reaction of ethyl 2-acetoxy-3-oxoheptanoate with γ-bromo-β-methoxy-<I>cis</I>-crotonate in the presence of sodium ethoxide afforded diethyl 3-methoxy-5-hydroxy-5-valeryl-2-hexenedioate (<B>7</B>) in 65% yield. Treatment of <B>7</B> with a dilute aqueous NaOH in acetone gave (±)-4-methoxy-6-valeryl-5,6-dihydro-2-pyrone, a key intermediate leading to pestalotin, in 41% yield.
- 公益社団法人 日本化学会の論文
著者
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Tsuboi Sadao
Department Of Applied Chemistry Faculty Of Engineering Okayama University
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Takeda Akira
Department Of Gastroenterology Osaka General Medical Center
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Amano Eiichiro
Department of Synthetic Chemistry, School of Engineering, Okayama University
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