分娩時における血中β-endorphinの動態と母体肥満の影響

概要

論文の詳細を見る
The relationship between maternal plasma levels of β-endorphin (β-Ep) during labor and various obstetrical factors was investigated in 115 healthy pregnant women. β-Ep was determined by radioimmunoassay using double-antibody RIA kit (INCSTAR Corporation, Stillwater, M'S.). The results were as follows:<BR>(1) The primiparous women showed a significant increase of maternal plasma levels of β-Ep at delivery compared with the multiparous women. In addition, the group of women whose Bishop's score at the onset of labor was 5 points or less showed a significant increase of maternal plasma levels of β-Ep at delivery compared with that in the group of women whose Bishop's score was 6 points or more.<BR>(2) The increase in maternal plasma levels of β-Ep during the first and the second stage of labor was significantly higher in obese women (pre-pregnancy BMI?24) than in normal weight women (pre-pregnancy BMI<24). In normal weight women in pre-pregnancy, the group of women whose weight gain during pregnancy was 11kg or more showed a significantly higher increase of β-Ep compared with that in the group of women whose weight gain was less than 11kg.<BR>These results suggest that a stressful delivery caused a significant increase of maternal plasma levels of β-Ep during labor. Moreover, obesity and marked weight gain during pregnancy caused a remarkable increase in β-Ep probably due to latent dystocia.
一般社団法人日本内分泌学会の論文