悪性脳腫瘍患者末梢血における細胞内サイトカイン(IFN-γ,IL-4)の測定意義

概要

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We have been analyzed the T cell subsets in brain tumor patients using by flow cytometry (FCM) and studied intracellular cytokine, such as interferon-γ, and interleukin-4. These cytokine were acummulated with newly developed Brefedin-αand β were analyzed the positive rates of IFN-γ(Th1), IL-4(Th2), and Th1/Th2 ratio by FCM. Twenty-eight brain tumor patients, such as 15 cases of malignant astrocytoma,10 cases of metastatic brain tumors, one case of malignant lymphoma and 2cases of germinoma were analyzed. Normal range of IFN-γ was 69.0±11.6%, IL-4 was 2.61±0.92%, and Th1/Th2 ratio was 14.15±6.84%. Time different of the IFN-γ/IL-4 for 2 days and age different were not recognized. The ratio of malignant astrocytoma and metastatic tumors was tendency to be decreased and all cases of malignant lymphoma and germinoma were definitely decreased. These results suggested that IFN-γ/IL-4 was influenced with the general and immunological status, and treatment in brain tumor patients.