gliomaにおけるcyst液中IL-6の定量解析

概要

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Interleukin 6(IL-6)is a lymphokine produced by a viriety of cells with pleiotropic functions and is one of the major immunomodulators. The production of IL-6 from human glioma cell in vitro has been reported. However, little is known about the production of IL-6 in vivo. We analysed IL-6 level of the glioma cyst fluid surgically collected. We examined cyst fluids from 4 of low grade glioma(grade I & II ),4 cases of grade III, and 10 grade IV, Although 1 case of low grade glioma showed high level of IL-6(more than 600 pg/ml), remaining 3 cases showed low level(less than 25 pg/ml). Two cases of 4 grade III gliomas showed low level, and remnining 2 cases showed 180 and 111 pg/ml. Five cases of 10 grade IV gliomas showed high level and 3 cases showed 317.6,149,30.7 pg/ml. Remainning 2 cases showed low level. Those results suggest that IL-6 level had a tendency to increase in high grade gliomas.
Kinki Brain Tumor Pathology Conferenceの論文