グリオーマの集学的療法 : 担脳腫瘍ラットによる実験および臨床例の検討

概要

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The effect of multidisciplinary therapy is discussed, focusing on the results of the combined use and single use of intracarotid injection of 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chlorocthyl)-3-nitrosourea hydrochloride (ACNU), fractionated irradiation by ^<60>lCo, and subcutaneous injection of OK-432 on brain tumor-bearing rats as well as on 31 human glioma cases. The experiments using brain tumor-bearing rats demonstrated the dose dependency of ACNU, and ACNU combined with ^<60>lCo irradiation resulted in an additive promoting effect, compared with the results of single use of each therapy. As for the mechanism of this effect, in addition to cell synchronization, thc cell-killing effect of ACNU enforced by the circulatory disturbance due to irradiation was shown by the histological study. Multidisciplinary therapy for clinical cases, on the other hand, demonstrated good results among 60% of glioblastoma patients and 73% of benign astrocytoma patients, resulting in an improved survival rate. In in vivo study, OK-432 showed no cytocidal effect; however, OK-432 was an important agent for clinical use as it was effective in maintaining the general condition, or in reducing side effects induced by the combined use of ACNU and ^<60>lCo irradiation.
日本脳神経外科学会の論文
1986-02-15