巨細胞性脳腫瘍における巨細胞についての形態学的解析

概要

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Although giant cells are often picked up in various brain tumors, the giant cell brain tumor is defined as giant cells inhabit the majority of the brain tumor. In clinical brain tumor pathology, giant cell brain tumors are diagnosed occasionally including giant cell glioblastoma and subependymal giant cell astrocytoma derived from neuronal epithelium, and giant cell tumor of bone derived from skull. In this study,5 cases of giant cell brain tumors including 2 cases of giant cell glioblastomas,2 cases of subependymal giant cell astrocytomas and one case of giant cell tumor of bone were investigated to observe the features of the giant cells in the brain tumors by optical microscope, immunohistochemistry and electron microscope. The results demonstrated that the largest average area of the giant cell were observed in the case of giant cell glioblastoma, and the smallest average area of the giant cell were observed in the case of subependymal giant cell astrocytoma, and the giant cell hold the most nucleus in the giant cell tumor of bone. Our data suggest that giant cells present respective characteristics in different giant cell brain tumors.
近畿脳腫瘍病理検討会の論文