52. 赤血球変形能からみた脳血管攣縮

概要

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Erythrocyte deformability was determined in 20 patients with cerebral vasospasm. The patients were divided into two groups according to degree of vasospasm, one with severe cerebral vasospasm, the other with mild cerebral vasospasm. Erythrocyte deformability, determined by modified Reid's method, was expressed as the variability of red blood cells (VRBC). Impaired deformability of erythrocytes is not specific for cerebrovascular disorders as this phenomenon has also been reported in peripheral vascular disorders. Decrease of erythrocyte deformability may be indicative of the existence of ischemia and/or lesions in some part of the body. In this study, we confirmed that erythrocyte deformability decreased with advancing the degree of cerebral vasospasm. There were significant differences (p<0.005) in VRBC in patients with severe cerebral vasospasm and in those with mild cerebral vasospasm. A previous study showed that pentoxifylline reduced platelet and erythrocyte aggregation, enhanced energy charge potential of the cell, and reduced blood viscosity. 13 patients received 300 mg pentoxifylline intravenously for 11 days and erythrocyte deformability was measured before and after this treatment. After treatment with pentoxifylline, erythrocyte deformability tended to increase in these patients.
The Japanese Society on Surgery for Cerebral Strokeの論文