再発astrocytic gliomaの形態学的研究 : 腫瘍細胞の巨細胞化および肥胖細胞化

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Morphological features and microscopic characteristics of the autopsied specimens of 14 adult cadavers with supratentorial recurrent gliomas were studied. One of the specific findings in the morphological change of the tumor cells was giant cell formation. These giant cells were subdivided into 3 types: 1) monstrous cell, 2) giant cell, and 3) gemistocytic cell. 1) Monstrous cells were found in 12 Cases, 4 grade 3 astrocytomas and 8 glioblastomas out of 14 recurrent liomas. These cells were defined as those larger than 150 μm in diameter and having bizarre, irregular and hyperchromatic multinuclei. The glial fibrillary acidic protein (GFAP) stain of monstrous cells was negative. These cells were scattered in the periphery of the tumor or necrosis. 2) Giant cells were demonstrated in 3 glioblastoma cases. They were 100-150 μm in diameter and had single or multiple nuclei. These cells were scattered in the periphery of both the tumor and necrosis, and contributed major cells of the tumor in two cases. The GFAP stain was negative in two cases and positive in one. 3) Gemistocytic cells were noted in 8 cases, 5 grade 3 astrocytomas and 3 glioblastomas, and were about 100 μm in diameter. They had a single distinct nucleus. The distribution of the cells was in the marginal zone of the tumor or necrosis, or grouped around vessels in the tumor. The GFAP stain was positive. These results suggest that the specific cells indicated herein may be degenerative changes of the tumor cells exposed while withstanding such adverse conditions as hypoxia, irradiation, and chemotherapy.
日本脳神経外科学会の論文
1987-04-15

再発astrocytic gliomaの形態学的研究 : 腫瘍細胞の巨細胞化および肥胖細胞化

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