鼻アレルギ-における抑制因子 (服部浩教授開講10周年記念論文集)

概要

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The effect of specific immunotherapy on the lymphocyte response was investigated in 18 untreated and 16 treated patients with house dust nasal allergy, and 5 non-atopic control subjects. The suppressor factor was induced with Dermatophagoides farinae (D. farinae) and the suppression of lymphocyte proliferative response (LPR) and the secretion of anti-D. farinae IgE antibody were measured.The percentages of suppression in the treated and control group were higher than in the untreated group. The suppressor factor reduced the LPR to D. farinae and the secretion of IgE antibody. In a previous study, the LPR to non-specific pokeweed mitogen and phytohemagglutinin were equal in three groups (allergic untreated and treated, and controls). The suppressor factor may be specific for D. farinae. In patients with high IgE antibody, even though immunotherapy was also used, the percentage of suppression was not increased satisfactorily.
耳鼻咽喉科臨床学会の論文