House dust鼻アレルギ-症例の減感作治療によるリンパ球応答について

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The effect of specific immunotherapy on the lymphocyte response has been evaluated in 26 untreated and 48 treated patients with house dust nasal allergy and also in 10 normal subjects. The methods employed are the determination of the number of histamine receptor leucocytes (HRL), serum level of the specific antibody to mite extract (Dermatophagoides farinae) and lymphocyte proliferation in response to the mite extract.Histamine receptor lymphocytes are found to be present in both of the B and T-cell fractions. Only the fraction of histamine receptor-bearing T lymphocyte responded to mite extract. The number of HRL was significantly greater in nasal allergy patients than that of normal subjects, but no changes were found as a result of immunotherapy. Lymphocyte proliferation in normal subjects in response to mite extract is rarely seen, whereas it almost always occurs in nasal allergy patients. In addition, the serum level of the specific IgE antibody is well correlated with the in vitro lymphocyte response to mite extract. Immunotherapy can produce a significant decrease in the lymphocyte activity to mite extract, especially in the presence of high concentrations of mite extract. The longer the duration of the immunotherapy for the nasal allergy patients, the smaller the activity of lymphocytes to mite extract. There were no significant differences between the untreated and treated patient groups with respect to the lymphocyte responsiveness to PHA and PWM as well as to the specific IgE antibody level.The results of the present study showed that the number of HRL and the serum level of specific IgE antibody were useful only for diagnosis, but not for the index of therapeutic effectiveness.

House dust鼻アレルギ-症例の減感作治療によるリンパ球応答について

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