D-Penicillamine Therapy for Rheumatoid Arthritis
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概要
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Thirty-four patients with rheumatoid arthritis who had failed to response to gold therapy were treated with D-penicillamine (Metalcaptase).Initial dose of 100 to 200mg per day was increased by 100mg in every two or four weeks, and the minimum dose which showed a effective response was maintained.In 65per cent of the patients, decreasing of duration of morning stiffness, articular index and increasing of grip strength were observed. Erythrocyte sedimentation rate decreased significantly in 82% of them after treatment.Side effects including skin rush pruritus, gastro-intestinal distress, edema, dizziness or proteinuria thrombopenia developed in 18 cases (52.9%).
著者
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