液液接触方式の模型バイオリアクタ- (バイオリアクタ-<特集>)

概要

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A novel membrane bioreactor suitable for liquid-liquid two phase enzymatic reactions is reviewed. The membrane bioreactor is based on the principle of liquid-liquid contact mode, and enables three points : (1) simultaneous achievement of both reaction and liquid-liquid separation, (2) containment of the enzyme in the bioreactor, and (3) realization of fully continuous operation. Engineering aspects are discussed such as kinds of membrane used, types of module applied, methods of enzyme immobilization, its scale-up etc. Several types of reaction to which the enzyme membrane bioreactor with liquid-liquid contact mode is successfully applied are introduced such as hydrolysis of fats and oils, synthesis of glycerides, glycerolysis of fats, transphosphatidylation of phospholipids, and chiral resolution. Enzymes involved in these reactions are lipase, phospholipase and peptidase.
日本膜学会の論文