Fumaric Acid, Anti-Thrombin Substance from Rhizopus javanicus
スポンサーリンク
概要
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An anti-thrombin substance (M2) was isolated from a culture broth of Rhizopus javanicus. Accumulation of M2 reached a maximum peak after 14 to 15 days of incubation and then decreased. The yield of M2 was 500 mg from 1 L of culture broth. M2 inhibited thrombin activity, and its 50% inhibition concentration in a reaction mixture containing 50μL of 12.5 NIH unit/mL thrombin and 200μL of 0.33% bovine fibrinogen was 63μM. M2 had a specific activity for thrombin, but it was less responsive to plasmin, tissue-type plasminogen activator, urokinase, plasma kallikrein and glandular kallikrein. The structure of M2 was identified as fumaric acid by elementary analysis, FAB/MS, 1H-NMR, 13C-NMR and IR spectra.
- 財団法人 学会誌刊行センターの論文
著者
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MIYAZAKI Yoshiko
Department of Food Science and nutrition, School of Human Life and Enviromental Science, mukogawa Wo
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Horie Noboru
School Of Human Environmental Science Mukogawa Women's University
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Horie Noboru
Department Of Food Science And Nutrition School Of Home Life And Environmental Sciences Mukogawa Wom
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Okamura Tokumitsu
Department Of Food Science And Nutrition School Of Home Life And Environmental Science Mukogawa Wome
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Ohsugi Masahiro
Department Of Food Science And Nutrition School Of Human Environmental Sciences Mukogawa Women'
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OHSUGI Masahiro
Department of Food Science and Nutrition, School of Home Life and Environmental Science, Mukogawa Women's University
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HORIE Noboru
Department of Food Science and Nutrition, School of Home Life and Environmental Science, Mukogawa Women's University
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OKAMURA Tokumitsu
Department of Food Science and Nutrition, School of Home Life and Environmental Science, Mukogawa Women's University
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MIYAZAKI Yoshiko
Department of Food Science and Nutrition, School of Home Life and Environmental Science, Mukogawa Women's University
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OHSUGI Masahiro
Department of Domestic Science, Mukogawa Womens University
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