Sjogren 症候群における唾液腺造影像の再検討

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55 patients, who had xerostomia or autoimmune diseases such as RA or SLE and were suspected as Sjögren's syndrome (Sjs) based on a sialogram of the parotis, were evaluated in order to clarify the relationship of the sialographical findings to the clinical and the histopathological findings of the salivary glands. The patients were classified into three groups according to Fukuda's sialographical classification for Sjs (Class I-Class IV). 32 patients were classified as Class II, which suggests an early stage of Sjs. 15 and 8 patients were classified into Class III and Class IV, which suggest advanced stages of Sjs, respectively. 46% of the patients classified as Class II, 77% of Class III and 67% of Class IV were diagnosed as keratoconjunctivitis sicca (KCS), and a high incidence of KCS was observed in the patients of each class. 44%, 67% and 13% of the patients classified as Class II, Class III and Class IV had another autoimmune disease. The amount of the salivary flow from the parotid gland in the patients classified as Class II, Class III and Class IV, stimulated by 10% citric acid, were 3.4 ± 1.5 ml/5 min, 2.8 ± 1.4 ml/5 min and 2.7 ± 1.7 ml/5 ml, respectively. The amount of the salivary flow in each class was lower than that of the normal healthy individuals (4.5 ± 1.5 ml/5 min), and as the sialographical classification advanced, a decreased salivary flow was noted. 22%, 87% and 88% of the patients, diagnosed as Class II, Class III and Class IV were indicated Sjs by a histopathological examination of the parotid and/or labial glands.
社団法人日本口腔外科学会の論文

Sjogren 症候群における唾液腺造影像の再検討

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