DNA analysis of oral leukoplakias by flow cytometry.

概要

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We investigated nuclear DNA contents of 21 oral leukoplakias by flow cytometry. Of the 21 leukoplakias, 6 cases (29%) were aneuploid. According to clinical examination, these leukoplakias were divided into a non-elevated type (10 cases), an elevated type (10 cases) and an elevated type with erosive lesion (1 case). One out of the 10 (10%) nonelevated cases, 4 out of the 10 (40%) elevated cases and 1 out of the 1 (100%) elevated case with erosive lesion were aneuploid. Histopathologicaly, marked epithelial dysplasia was noted in 3 cases and moderate dysplasia was observed in 10 cases. No obvious dysplasia was seen in the other 8 cases. Two out of the 3 (67%) cases with marked dysplasia, 2 out of the 10 (20%) with moderate dysplasia and 2 out of the 8 (25%) without obvious dysplasia were aneuploid.
社団法人日本口腔外科学会の論文