Relationship between sialographical and immunological findings of Sjoegren's syndrome.

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42 patients, suspected as having Sjögren's syndrome (88) based on sialogram of the parotid gland and were diagnosed as not having other autoimmune diseases, were evaluated in order to clarify the relationship of the sialographical appearance to immunological findings of SS. According to Fukuda's sialographical classification for SS (Class I-Class IV), tin patients were classified into three groups. 21 patients were classified as Class II, which suggests an early stage of SS. 8 patients were classified into Class III and 13 into Class IV. which suggest advanced stages for SS. Class I was not observed in this group of patients. Numbers of both peripheral blood leukocytes (leu) and lymphocytes (lym) of Class 17 patients (leu: 4, 200/mm3, lym: 1, 400/mm3) were significantly lower than those of Class II patients (leu: 5, 900/mm3, lym: 1, 900/mm3). Increase in γ-globulin, IgA, IgG and IgM in the sera of the patients was also observed as the sialographical classification advanced. Serum anti-nuclear antibody (ANA) and rheumatoid factor (RF) were observed in 43% and 38% of Class II patients, 63% and 50% of Class III patients, and 67% and 75% of Class IV patients, respectively. A high incidence of ANA and RF were observed also in Class II patients, and increases in the incidence of the above factors were seen as the sialographical classification advanced. Serum anti-SS-A antibody and anti-SS-B antibody were demonstrated in 57% and 29% of Class III patients, and 88% and 38% of Class IV patients. In contrast, the above antibodies were not observed in the sera of Class II patients.
社団法人日本口腔外科学会の論文

Relationship between sialographical and immunological findings of Sjoegren's syndrome.

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