Undifferentiated Sarcoma of the Salivary Gland in a Mongolian Gerbil (Meriones unguiculatus)
スポンサーリンク
概要
- 論文の詳細を見る
A subcutaneous mass was found in the lower ventral neck region of a 55-week-old male Mongolian gerbil (Meriones unguiculatus). Histopathologically, the mass involved salivary glands and featured diffuse proliferation of pleomorphic neoplastic cells with large necrotic foci. The lesion was well demarcated from the surrounding tissue, although invasive growth to fibrous septa was occasionally observed. The neoplastic cells were mainly arranged in irregular sheets with severe cellular atypia, round to oval nuclei and varying amounts of eosinophilic cytoplasm. Mitotic figures and multinucleated giant cells were frequent. Immunohistochemical analysis revealed that the neoplastic cells were strongly positive for vimentin and S-100 and negative for NSE, cytokeratin, α-SMA, c-kit, factor VIII, CD34, α-1-antitrypsin, lysozyme and MSR-A. Based on the results, the mass was diagnosed as an undifferentiated sarcoma of the salivary gland. To the best of our knowledge, this is the first report of such a tumor in Mongolian gerbils.
- 日本毒性病理学会の論文
著者
-
Cho Young-man
Division Of Pathology National Institute Of Health Sciences
-
Tsukamoto Tetsuya
Division Of Oncological Pathology Aichi Cancer Center Research Institute
-
Nishikawa Akiyoshi
Division Of Pathology Biology Safety Research Center National Institute Of Health Sciences
-
Taniyama T
Okayama Univ. Okayama
-
Tsukamoto Takahisa
Division Of Oncological Pathology Aichi Cancer Center Research Institute
-
Takasu Shinji
Division Of Oncological Pathology Aichi Cancer Center Research Institute
-
Toyoda Takeshi
Division Of Oncological Pathology Aichi Cancer Center Research Institute
-
Toyoda Takeshi
Division Of Materials Science And Engineering Graduate School Of Engineering Hokkaido University
-
Ogawa Kumiko
Division of Pathology, National Institute of Health Sciences
-
Onami Saeko
Division of Pathology, National Institute of Health Sciences
-
Shi Liang
Production and Technology Center, Mitsui Chemicals Inc.
-
Saito Ayumi
Department of Pathology and Matrix Biology, Mie University Graduate School of Medicine
-
Matsuo Saori
Division of Pathology, National Institute of Health Sciences
-
Tatematsu Masae
Japan Bioassay Research Center
-
Ogawa Kumiko
Division Of Pathology National Institute Of Health Sciences
関連論文
- A 55-week chronic toxicity study of dietary administered kojic acid (KA) in male F344 rats
- Increased H-ras mutation frequency in mammary tumors of rats initiated with N-methyl-N-nitrosourea (MNU) and treated with acrylamide
- Lack of modifying effects of prepubertal exposure to acrylamide (AA) on N-methyl-N-nitrosourea (MNU)-induced multi-organ carcinogenesis in F344 rats
- Enhancement of esophageal carcinogenesis in acid reflux model rats treated with ascorbic acid and sodium nitrite in combination with or without initiation
- Inhibitory Effects of Octreotide Acetate, a Somatostatin Analog, on Spontaneous Chronic Pancreatitis in WBN/Kob Rats
- Rapid Screening for Chemopreventive Agents in Herbal Extracts in a PhIP Rat Model with DNA Adduct and Cell Proliferation as End-Points
- DNA Adduct Formation, Nucleolar Segregation and Cell Proliferation in Rats Treated with 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
- Depression of T cell-mediated immunity reduces sulfadimethoxine-induced capsular inflammation and inhibits associated development of invasive thyroid follicular cell carcinomas in rats
- Lack of enhancement of susceptibility to mammary and thyroid carcinogenesis in rats exposed to DMBA and DHPN following prepubertal iodine deficiency
- In vivo mutagenicity and initiation following oxidative DNA lesion in the kidneys of rats given potassium bromate
- Dose-dependent promotion of rat forestomach carcinogenesis by combined treatment with sodium nitrite and ascorbic acid after initiation with N-methyl-N'-nitro-N-nitrosoguanidine : Possible contribution of nitric oxide-associated oxidative DNA damage
- In vivo mutagenicity and oxidative DNA damage in the livers of gpt delta mice treated with flumequine(Mutagenicity, Carcinogenicity, Proceedings of the 32nd Annual Meeting)
- Lack of Initiating Activity of Kojic Acid on Hepatocarcinogenesis in F344 Rats
- Roles of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 expression and β-catenin activation in gastric carcinogenesis in N-methyl-N-nitrosourea-treated K19-C2mE transgenic mice
- Lack of association between CpG island methylator phenotype in human gastric cancers and methylation in their background non-cancerous gastric mucosae
- Inhibitory effect of nordihydroguaiaretic acid, a plant lignan, on Helicobacter pylori-associated gastric carcinogenesis in Mongolian gerbils
- Organ-dependent susceptibility of p53 knockout mice to 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)
- Gastric adenocarcinoma with chief cell differentiation
- Effects of eradication of Helicobacter pylori on gastric carcinogenesis in experimental models
- Helicobacter pylori infection stimulates intestinalization of endocrine cells in glandular stomach of Mongolian gerbils
- Significant Factors on Gastric Carcinogenesis Revealed by Experimental Animal Models
- Gastric and intestinal phenotypes and histogenesis of advanced glandular stomach cancers in carcinogen-treated, Helicobacter pylori-infected Mongolian gerbils
- Colonic and small-intestinal phenotypes in gastric cancers : Relationships with clinicopathological findings
- Susceptibility of Heterozygous and Nullizygous p53 Knockout Mice to Chemical Carcinogens : Tissue Dependence and Role of p53 Gene Mutations
- Coexistence of gastric-and intestinal-type endocrine cells in gastric and intestinal mixed intestinal metaplasia of the human stomach
- Eradication of Helicobacter pylori induces apoptosis and inhibits proliferation of heterotopic proliferative glands in infected Mongolian gerbils
- P6-38 Relationship between hepatic enzyme induction and carcinogenicity in the p53 deficient mice treated with aminophenylnorharman(DRUG METABOLISM/CARCINOGENICITY)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- β-Catenin gene alteration in glandular stomach adenocarcinomas in N-methyl-N-nitrosourea-treated and Helicobacter pylori-infected Mongolian gerbils
- Immunohistochemically detectable Cdx2 is present in intestinal phenotypic elements in early gastric cancers of both differentiated and undifferentiated types, with no correlation to non-neoplastic surrounding mucosa
- Detection of Initiating and Promoting Activity of Aminophenylnorharman with a Five-week In Vivo Initiation Assay
- Frequent hypomethylation in multiple promoter CpG islands is associated with global hypomethylation, but not with frequent promoter hypermethylation
- β-Catenin mutations and nuclear accumulation during progression of rat stomach adenocarcinomas
- Tissue-dependent susceptibility of p53 knockout mice to chemical-induced carcinogenesis (CARCINOGENICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Effect of early eradication on Helicobacter pyloirirelated gastric carcinogenesis in Mongolian gerbils
- Gastric Carcinogenesis and Intestinalization Induced by N-methyl-N-nitrosourea in the Senescence-Accelerated Mouse (SAMP3)
- Earlier Helicobacter pylori Infection Increases the Risk for the N-Methyl-N-nitrosourea-induced Stomach Carcinogenesis in Mongolian Gerbils
- Tongue Carcinogenic Susceptibility of p53 Deficient Mice to Methyl-n-amylnitrosamine
- Cloning of the 5' Upstream Region of the Rat p16 Gene and Its Role in Silencing
- Synergistic Promoting Effects of Helicobacter pylori Infection and High-salt Diet on Gastric Carcinogenesis in Mongolian Gerbils
- Lack of a Dose-response Relationship for Carcinogenicity in the Rat Liver with Low Doses of 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline or N-Nitrosodiethylamine
- Appearance of Osteonectin-expressing Fibroblastic Cells in Early Rat Stomach Carcinogenesis and Stomach Tumors Induced with N-Methyl-N'-nitro-N-nitrosoguanidine
- The Effects of Allyl Alcohol-induced Cell Proliferation for Detection of Initiation Activities of Chemicals in Rat Liver
- Preneoplastic Changes of Stomach Cancer : Mice, Rats and Mongolian Gerbils
- Reversibility of Heterotopic Proliferative Glands in Glandular Stomach of Helicobacter pylori-infected Mongolian Gerbils on Eradication
- Differential Effects of Partial Hepatectomy and Carbon Tetrachloride Administration on Induction of Liver Cell Foci in a Model for Detection of Initiation Activity
- Mouse Strain Susceptibility to Diethylnitrosamine Induced Hepatocarcinogenesis Is Cell Autonomous Whereas Sex-susceptibility Is Due to the Micro-environment:Analysis with C3H【tautomer】BALB/c Sexually Chimeric Mice
- New animal model of glandular stomach carcinogenesis in Mongolian gerbils infected with Helicobacter pylori and treated with a chemical carcinogen
- Sparse Distribution of Hepatocyte Growth Factor-producing Cells inside Hepatocellular Foci in Rats Treated with Hepatocarcinogens
- P7-44 Toxicity Evaluation of Bt protein with 28-days dietary administration to gastric-acid reduced rat models(GENERAL TOXICITY)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- P6-43 Screening of chemopreventive agents using a medium-term pancreas carcinogenesis model in hamsters(DRUG METABOLISM/CARCINOGENICITY)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- Dose-related changes of oxidative stress and cell proliferation in kidneys of male and female F344 rats exposed to potassium bromate
- Enhancement of urinary bladder carcinogenesis by combined treatment with benzyl isothiocyanate and N-butyl-N-(4-hydroxybutyl) nitrosamine in rats after initiation
- A possible role of oxidative stress in potassium bromate (KBrO_3) carcinogenesis (ACTIVE OXYGEN) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Synergistic interaction between excess caffeine and deficient iodine on the promotion of thyroid carcinogenesis in rats pretreated with N-bis(2-hydroxypropyl) nitrosamine
- Lung as a new target in rats of 2-amino-3-methylimidazo[4,5-f]quinoline carcinogenesis : Results of a two-stage model initiated with N-bis(2-hydroxypropyl)nitrosamine
- In vivo Approaches to Study Mechanism of Action of Genotoxic Carcinogens
- The Mouse rasH2/BHT Model as an in vivo Rapid Assay for Lung Carcinogens
- Enhancement by Cigarette Smoke Exposure of 2-Amino-3,8-dimethylimidazo [4,5-f] quinoxaline-induced Rat Hepatocarcinogenesis in Close Association with Elevation of Hepatic CYP1A2
- Prevention by 2-Mercaptoethane Sulfonate and N-Acetylcysteine of Renal Oxidative Damage in Rats Treated with Ferric Nitrilotriacetate
- Development of invasive follicular cell carcinomas in a rat thyroid carcinogenesis model : Biological impact of capsular inflammation and reduced cyclooxygenase-2 expression
- Enhancing effects of carbon tetrachloride on in vivo mutagenicity in the liver of mice fed 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)
- Effects of co-treatment of dextran sulfate sodium and MeIQx on genotoxicity and possible carcinogenicity in the colon of p53-deficient mice
- Involvement of Lipid Peroxidation in Spontaneous Pancreatitis in WBN/Kob Rats
- Morphological characterization of the ovary under normal cycling in rats and its viewpoints of ovarian toxicity detection
- STEM CELLS AND GASTRIC CANCER : ROLE OF GASTRIC AND INTESTINAL MIXED INTESTINAL METAPLASIA
- Stem cells and gastric cancer : Role of gastric and intestinal mixed intestinal metaplasia
- Renal Carcinogenicity of Concurrently Administered Fish Meal and Sodium Nitrite in F344 Rats
- Inhibition by β-Carotene of Upper Respiratory Tumorigenesis in Hamsters Receiving Diethylnitrosamine Followed by Cigarette Smoke Exposure
- Enhancing Effects of Quinacrine on Development of Hepatopancreatic Lesions in N-Nitrosobis (2-oxopropyl) amine-initiated Hamsters
- Mechanistic Insights into Chemopreventive Effects of Phenethyl Isothiocyanate in N-Nitrosobis (2-oxopropyl) amine-treated Hamsters
- "P-34 Inhibitory Effects of 2-Mercaptoethane Sulfonate on the Development of Cholangiofibrosis in Rats induced by N-Nitrosopyrrolldine.
- "P-26 Long-term Effects of Cortisol Acetate on Rat Pancreas.
- Chemopreventive Effects of 3-Phenylpropyl Isothiocyanate on Hamster Lung Tumorigenesis Initiated with N-Nitrosobis (2-oxopropyl) amine
- Synergistic Effects of High-dose Soybean Intake with Iodine Deficiency, but Not Sulfadimethoxine or Phenobarbital, on Rat Thyroid Proliferation
- Lack of Effect of Soy Isoflavone On Thyroid Hyperplasia in Rats Receiving an Iodine-deficient Diet
- P-14 Effects of antioxidants on spontaneous hepatic and renal lesions in LEC rats.(Proceedings of the 27th Annual Meeting)
- Lack of Modification by Environmental Estrogenic Compounds of Thyroid Carcinogenesis in Ovariectomized Rats Pretreated with N-bis(2-hydroxynronyl)nitrosamine (DHPN)
- Lack of Modifying Effects of Environmental Estrogenic Compounds on the Development of Thyroid Proliferative Lesions in Male Rats Pretreated with N-Bis(2-hydroxypropyl)nitrosamine(DHPN)
- Inhibitory Effects of 1'-Acetoxychavicol Acetate on N-Nitrosobis(2-oxopropyl)-amine-induced Initiation of Cholangiocarcinogenesis in Syrian Hamsters
- Concurrent Administration of Fish Meal and Sodium Nitrite Does not Promote Glandular Stomach Carcinogenesis in Rats after Treatment with N-methyl-N'-nitro-N-nitrosoguanidine
- REVISION AND ESTABLISHMENT OF JAPANESE DRINKING WATER QUALITY GUIDELINES FOR DI(2-ETHYLHEXYL) PHTHALATE, TOLUENE AND VINYL CHLORIDE : DIFFERENCES FROM THE LATEST WHO GUIDELINE DRAFTS
- Antimutagenic and Anticarcinogenic Properties of Kyo-yasai, Heirloom Vegetables in Kyoto
- Sesamin, a lignan of sesame, down-regulates cyclin D1 protein expression in human tumor cells
- A Review of Nomenclature and Diagnostic Criteria for Proliferative Lesions in the Liver of Rats by a Working Group of the Japanese Society of Toxicologic Pathology
- 22D-10-1 Effects of Oltipraz on Spontaneous Hepatitis of LEC Rats.
- Isolation of Differentiated Squamous and Undifferentiated Spindle Carcinoma Cell Lines with Differing Metastatic Potential from a 4-Nitroquinoline N-Oxide-induced Tongue Carcinoma in a F344 Rat
- Effects of Continuous Hepatitis with Persistent Hepatitis C Viremia on Outcome after Resection of Hepatocellular Carcinoma
- Hexosaminidase-altered Aberrant Crypts, Carrying Decreased Hexosaminidase α and β Subunit mRNAS, in Colon of 1,2-Dimethylhydrazine-treated Rats
- Uterine Carcinosarcoma in a 2-year-old Female Wistar Hannover GALAS Rat
- Rhabdomyosarcoma in the Abdominal Cavity of a 12-Month-Old Female Donryu Rat
- Inhibitory effects of aminoguanidine on thyroid follicular carcinoma development in inflamed capsular regions of rats treated with sulfadimethoxine after N-bis(2-hydroxypropyl)nitrosamine-initiation
- Impact of oral corticosteroid use for idiopathic osteonecrosis of the femoral head : a nationwide multicenter case-control study in Japan
- Undifferentiated Sarcoma of the Salivary Gland in a Mongolian Gerbil (Meriones unguiculatus)
- Toxic effects of a horseradish extract and allyl isothiocyanate in the urinary bladder after 13-week administration in drinking water to F344 rats
- Female heterozygous (+/fa) Zucker rats as a novel leptin-related mammary carcinogenesis model
- Uterine Carcinosarcoma in a 2-year-old Female Wistar Hannover GALAS Rat
- Undifferentiated Sarcoma of the Salivary Gland in a Mongolian Gerbil (Meriones unguiculatus)
- Rhabdomyosarcoma in the Abdominal Cavity of a 12-Month-Old Female Donryu Rat
- Expression of Cathepsin E and Its Suppression with Intestinalization in Epithelial Cells and Tumor Cells in Rat Glandular Stomach Treated with N-methyl-N'-nitro-N-nitrosoguanidine
- Preneoplastic Changes of Stomach Cancer. Mice, Rats and Mongolian Gerbils.:—Mice, Rats and Mongolian Gerbils—