Desmoplastic Spitz nevus の1例

概要

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Spitz nevus is a rare form of benign melanocytic nevus, which can be difficult to differentiate from malignant melanoma because of the presence of bizarre nevus cells. We experienced such a controversial case of a 25-year-old man suffered from a nodule on the left ankle joint. The black nodule of 6-7mm in diameter had grown slowly during the past five years. Histopathologically, the excised specimen showed features of a dermal nevus. Tumor cells were mainly composed of epithelioid cells and partially of spindle cells. Cytoplasm of the tumor cells was large and eosinophilic. Although nuclei showed pleomorphism and multiplicity occasionally. We diagnosed the tumor as a Spitz nevus because of symmetry of the architecture, sharp lateral and deep margins, presence of maturation, and sparcity of the mitotic figures. Stroma of the tumor was filled with fibrous tissue. Then desmoplastic variety was considered.
日本皮膚悪性腫瘍学会の論文
1997-11-30