皮膚B細胞リンパ腫の1例

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We report a case of cutaneous B cell lymphoma in a 29-year-old male. About one and half years before consultation, he noticed firm and red colored nodules on his left knee.Histopathological examination revealed a dense infiltrate of large lymphoid cells with mitotic figures in the dermis. In an immunohistochemical study, most of these cells were found to be positive for CD20. Southern blot analysis demonstrated rearranged bands in the immunoglobulin heavy-chain gene. On physical examination lymph node swelling was not noted. CT and Ga scintigraphy showed no evidence of metastasis. The patient was diagnosed as having malignant lymphoma of the diffuse, large cell type by REAL classification associated with cutaneous B cell lymphoma, stage 1A, by Burgs staging.Excision of the lesion with a 2cm margin was performed followed by local irradiation with a total dose of 30Gy.