:Special Reference to Variant ALP

概要

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The so-called variant ALP, one of the ALP isoenzyme, was detected in 17 of 94 (18.1%) patients with hepatocellular cancer using the polyacrylamide gradient gel electrophoresis. This isoenzyme seemed to have high specificity for hepatocellular cancer because it was not found in patients with benign hepatobiliary diseases and cancers except hepatocellular cancer.Prevalence of variant ALP was lower than those of AFP (400ng/ml<) and novel γ-GTP which had been reported to be specific for hepatocellular cancer in our previous publication. The other hand, the appearance of variant ALP had no relation to serum titer of AFP and the positivity of novel γ-GTP and, in 4 of 94 patients with hepatocellular cancer, this isoenzyme was only detected among these three markers.Now, we have no valuable tumor marker for diagnosis of hepatocellular cancer in which serum levels of AFP is low and novel γ-GTP is negative.Therefore, examination of variant ALP combined with AFP and novel γ-GTP is expected as one of useful biochemical approaches.
財団法人日本消化器病学会の論文