肝細胞癌における各種腫瘍マ-カ-の診断能に関する研究--特にAFP陰性例と各進行度における検討を中心に
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The purpose of this study was to evaluate whether concurrent measurements of various tumor markers mentioned below can improve the diagnostic efficiency in hepatocellular carcinoma (HCC) with special reference to AFP-low or-negative patients, and to analyze the usefulness of these markers in relation to staging and in the early diagnosis of HCC. The author concurrently determined four markers consisting of noverl γ-GTP isoenzyme (Novel γ-GTP), variant alkaline phosphatase (VAALP), basic fetoprotein (BFP) and CEA in addition to AFP in 162 patients having HCC.<BR>Serum AFP levels below 400ng/ml, a condition commonly seen in sera of hepatobiliary diseases other than HCC were obtained in 70 out of 162 patients, or 43%. There was little correlation among positivities of these markers, and the diagnostic usefulness was increased by combination assay of these markers except in the case of CEA. Specific diagnosis of HCC could be made in 75% by a combination of Novel γ-GPT and VAALP in addition to AFP. Moreover, diagnosis of an existing malignancy could be made in 83% by BFP in addition to AFP, Novel γ-GTP and VAALP. Positive ratios of BFP and CEA increased in proportion to staging, whereas those of AFP and Novel γ-GTP were independent of the stage and relatively high even in patients within the early stage. In general, incidences of these markers were relatively lower in patients having samll HCC, however markers of a secreting type as AFP and Novel γ-GTP were relatively useful for early diagnosis of HCC.
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関連論文
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- 肝細胞癌における各種腫瘍マ-カ-の診断能に関する研究--特にAFP陰性例と各進行度における検討を中心に
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