HBsAg NEGATIVE HEPATITIS RELATION TO EPSTEIN-BARR VIRUS, CYTOMEGALOVIRUS AND HERPES SIMPLEX VIRUS

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An attempt was undertaken to study possible role of cytomegalovirus, EB virus and herpes simplex virus for the development of HBsAg negative hepatitis. The subjects com-posed of 36 cases with HBsAg negative liver disease (group A), 35 cases with HBsAg positive liver disease (group B), with six control cases. Serum antibodies of cytomegalovirus, herpes simplex virus were measured by complement fixation test, these of EB virus was observed 8 cases in Group A(23%), and 1 case in Group B(3%). An elevated titer of cytomegalovirus antibody was found in 5 cases in Group A(14%), and 1 cases in Group B(3%). There was an increased titer of herpes simplex virus in one each of Group A(3%) and Group B(3%). In HBsAg negative liver disease, the tier of EB virus and cytomegalovirus anti-body tended to be higher than in cases of HBsAg positive chronic liver disease. Of 8 cases with a high titer of EB virus, 4 had cryptogenic liver cirrhosis and 4 of them also revealed an elevated value of cytomegalovirus antibody later.From the result, it is suggested that in some patients cytomegalovirus and EB virus may participate in the development of HBsAg negative hepatitis.
財団法人日本消化器病学会の論文