AN ESTABLISHMENT OF ASSAY FOR SERUM RIBONUCLEASE ACTIVITY AND ITS CLINICAL SIGNIFICANCE

概要

論文の詳細を見る
The method for determination of serum ribonuclease (RNase) activity was established using Poly(C) as synthetic substrate. In healthy subjects the RNase activity was 118±2.7 units/ml/min. The value over 2 SD of the mean, i.e. 185 units/ml/min. being taken as abnormal, 95% of pancreatic cancer and 38.5% of other cancerous diseases revealed to be abnormal. Hepatic cancer and lung cancer showed relatively high value, while cancer of gastrointestinal tracts rather low value. In renal insufficiency the RNase activity was high and showed a good correlation with BUN. Besides, hepatic diseases as liver cirrhosis and hepatic cancer were of rather high value, which was reversely correlated with serum albumin and cholinesterase. It was, thus, suggested that serum RNase might derive from pancreas, and that the liver and the kidney might be involved in the increase of its activity. In this connection, the determination of serum RNase activity may be useful for the serological diagnostic tool of pancreatic cancer.
財団法人日本消化器病学会の論文