Pancreatic exocrine secretion in response to subcutaneous injection of caerulein in rats.

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The secretory dynamics of pancreatic juice and protein output in response to a single subcutaneous injection of caerulein (0.1-100μg/kg body weight) were studied in the anesthetized rat. The subcutaneous injection of caerulein at a dose of 0.1μg/kg body weight caused only a slight increase of pancreatic exocrine secretions. Caerulein with doses ranging from 1.25 to 10μg/kg body weight caused a single peaked response of pancreatic juice flow and protein output being maximum during 0-20min after caerulein injection. In contrast, higher doses of caerulein caused two peaks of exocrine pancreatic response, which were seen during 0-20min (first peak) and again during 60-80min (second peak) after the subcutaneous injection of caerulein. Both peaks of exocrine responses showed a biphasic dose-response curve. The first peak of pancreatic exocrine secretions became maximum with 1.25μg/kg body weight of caerulein and then decreased with supramaximal concentrations. On the other hand, second peak of exocrine pancreatic responses increased as the caerulein concentration increased, became maximum with 20μg/kg body weight and then decreased with higher concentrations. When 20μg/kg body weight of caerulein was injected repeatedly 60min after the first caerulein (20μg/kg body weight) injection, the second increase of pancreatic exocrine seretions induced by the first injection was significantly inhibited during 60-100min. The present study revealed that the secretory pattern of exocrine pancreas in response to a single subcutaneous injection of caerulein was quite different (single- or two-peaked response) depending on the injected doses.
財団法人日本消化器病学会の論文

Pancreatic exocrine secretion in response to subcutaneous injection of caerulein in rats.

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