EFFECTS OF EIGHT AMINO ACIDS ON THE EXOCRINE AND ENDOCRINE PANCREATIC FUNCTION

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The inhibitory effects of eight amino acids on the exocrine and endocrine pancreatic function were studied in mongrel dogs with chronic gastric and pancreatic fistulae. Each amino acid was given intravenously under the basal stimulation with secretin and pancreozymin.Inhibition of the pancreatic exocrine function in volume of the pancreatic juice and amylase output were caused by Asparagine, Arginine, Isoleucine and Phenylalanine.Their highest decreasing ratio were 23% and 53%, 15% and 27%, 13% and 27%, 14% and 19% respectively. However, no significant changes were shown in bicarbonate concentration. There were no significant inhibition by Threonine, Glycine and Methionine in volume, amylase and becarbonate. On the other hand, Valine caused increase in volume and amylase output. The highest increasing ratio were 13% and 15% respectively.With those amino acids infusion which caused inhibition of the exocrine pancreatic function, the rise in the serum levels of IRG were demonstrated, but no significant change in the serum level of IRI was illustrated in each amino acid infusion.
財団法人日本消化器病学会の論文