Effects of biliary diversion on pancreatic function.
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概要
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The aim of this study was to investigate the effect of biliary diversion upon the pancreatic exocrine secretion in dogs with chronic pancreatic fistula.Response of pancreatic exocrine secretion to intravenous administration of various doses of pancreozymin and secretin was estimated before and after biliary diversion.Biliary diversion suppressed the response of pancreatic exocrine secretion to low doses of pancreozymin and secretin. On the contrary, higher response of pancreatic exocrine secretion occurred after biliary diversion than before under high doses of pancreozymin and secretin administration. Though plasma insulin and gastrin levels showed no significant changes before and after biliary diversion, plasma glucagon levels elevated significantly after biliary diversion.Elevation of plasma pancreatic glucagon levels after biliary diversion might contribute to the suppression of the response of pancreatic exocrine function to low doses of pancreozymin and secretin administration.
- 財団法人 日本消化器病学会の論文
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