Experimental Study of Effects of Hypertonic Glucose and Amino Acids Infusion on Pancreatic Exocrine Secretion

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The inhibition of pancreatic exocrine secretion by hypertonic glucose and amino acids infusion was studied in dogs with chronic pancreatic fistula and open gastric fistula. Under the background infusion of secretin and pancreozymin, 20% glucose, 30% glucose and 12% amino acids were given by intravenous infusion for an hour. Bicarbonate concentration were not showed an inhibitory, but showed depression in volume and enzyme secretion. Maximal percent decrease in volume and amylase output by infusion of each solutions were 23% and 11% (20% glucose), 32% and 29% (30% glucose) and 53% and 42% (12% amino acids) respectively. In infusion of hypertonic glucose, it was appeared parallel in the effect of inhibitory with degree of elevation in blood sugar and IRI. IRI and IRG were increased markedly in amino acids infusion.
財団法人日本消化器病学会の論文