HLA ANTIGENS IN COLORECTAL CANCER, ADENOMAS AND INFLAMMATORY BOWEL DISEASE

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HLA antigens were studied in 60 patients with colorectal cancer, 43 with colorectal adenomas, 60 with ulcerative colitis, 10 with Crohn's disease and 120 healthy Japanese controls. HLA typing was performed by the microdroplet lymphocyte cytotoxicity test. From these studies, the following results were obtained.1) Seventeen of the 60 (28%) patients with colorectal cancer were found to have Bw35, compared to 10% of controls (P<0.005). In the patients with colorectal adenomas, the frequency of Bw40 was 56% vs 35% in the normal population and the frequency of B5 was decreased (P<0.02 and P<0.005, respectively). When the frequencies of antigens in the patients with adenomas were compared with those with cancer, a decreased frequency of B5 was found in the former group (P<0.05).2) B5 was recognized in 62% of the patients with ulcerative colitis, compared to 40% of controls (P<0.01). Furthermore, B7 was decreased in frequency (P<0.05) and there was the highest relative risk value for A3 (R.R.=6.3). When the patients were classified into 3 types according to the extent of the lesions, total colitis, left-sided colitis and proctitis, B5 was recognized in 65% of the patients with left-sided colitis or total colitis and this was statistically significant. However, no significant difference in the frequency of B5 was recognized between the patients with proctitis and the controls, probably due to small number of studied cases to evaluate.3) In the patients with Crohn's disease, B27 was recognized in one patient and was increased in frequency (P<0.001), although the number of patients studied was very small.

HLA ANTIGENS IN COLORECTAL CANCER, ADENOMAS AND INFLAMMATORY BOWEL DISEASE

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