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Motilin has been investigated in relation to gut motility, however, the effect of gut hormones on the release of motilin has not been fully elucidated: We have, therefore, investigated the effect of glucagon on the release of motilin in normal subjects and the patients with peptic ulcer. Intravenous administration of glucagon caused a decrease of plasma motilin concentrations dosedependently. In addition, glucagon inhibited the release of motilin induced by test meal ingestion or intraduodenal acidification in normal subjects. In patients with gastric ulcer or duodenal ulcer, a decrease of plasma motilin concentrations by glucagan infusion was observed, on the contrary, a marked increase of plasma motilin concentrations, "paradoxical response", by glucagon infusion was found in the patients with Zollinger-Ellison syndrome.
財団法人日本消化器病学会の論文