Serum levels of N-terminal type III procollagen peptide in inflammatory bowel disease.

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We measured the serum levels of the N-terminal peptide of type III procollagen (P-III-P) in patients with Crohn's disease and ulcerative colitis in order to clarify the differences in collagen metabolism between the two diseases.<BR>The mean level of serum P-III-P in Crohn's disease at remission was 16.5ng/ml, which was significantly higher than that in Crohn's disease at the active stage and that in ulcera-tive colitis. In the sera of patients with Crohn's disease who had received hyperalimentation alone without oral intake or drugs, the P-III-P levels increased gradually after the beginning of treatment and remained high for 3 months after induction of remission. However, in the sera of patients with Crohn's disease who had received prednisolone in addition to hyperalimentation, no elevation in the levels of P-III-P was observed. In the sera of patients with ulcerative colitis, most of whom had received prednisolone, the P-III-P levels showed no significant difference between the active stage and remission.<BR>The present results suggest that additional prednisolone therapy may prevent excessive collagen production in patients with Crohn's disease at the early remission stage and that some differences in collagen metabolism may exist between this disease and ulcerative colitis.
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