ラットの組織における脂質過酸化および水銀の蓄積に及ぼす食餌性脂質の影響

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Two groups of male Wister rats, 10 animals each, were fed vitamin-E deficient diets containing either of two kinds of lipid, beef tallow containing less amount of polyunsaturated fatty acid or cod-liver oil containing much of one. At the end of 5 weeks (35 days) on these diets, 4 animals from each group were measured for the amounts of expired ethane and pentane, followed by sacrifice for analyses of the fatty acid compositions of the lipids and the contents of thiobarbituric acid (TBA)-reactants in the plasma, brain, liver and kidney, and the level of oxidative hemolysis. The remaining 6 animals in each group were subcutaneously injected with 1.25mg methylmercury daily for 5 consecutive days and the blood cells, liver, kidney and brain were analyzed for total and inorganic mercury. Results obtained were as follows:1) The fatty acid compositions of the plasma, liver, kidney and brain were changed by the effects of dietary lipid components, in that the concentrations of polyunsaturated fatty acids of the ω-3 series increased significantly in the group fed the diet containing cod-liver oil as compared with the group fed the diet containing beef tallow.2) The amount of expired ethane, the levels of TBA-reactants in the plasma, liver, kidney and brain, and the level of oxidative hemolysis were significantly higher in the group fed the diet containing cod-liver oil than in the group fed the diet containing beef tallow, suggesting that lipid peroxidation might be stimulated and that the erythrocyte membrane might be weakened in the rats fed a vitamin-E deficient diet containing much amount of the ω-3 series polyunsaturated fatty acid.3) The inorganic mercury content in the brains of rats fed the diet containing cod-liver oil was significantly higher than in those fed the diet containing beef tallow, suggesting that the lipid peroxidation induced by dietary polyunsaturated fatty acids affects membrane permeability and thus facilitates the sotrage of mercury in the brain.
日本衛生学会の論文

ラットの組織における脂質過酸化および水銀の蓄積に及ぼす食餌性脂質の影響

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